复方脑栓1号对血细胞解聚效应的实验研究

STUDY ON THE EFFECT OF "FUFANG NAOSIIUAN -1" ON DISAGGREGATION OF BLOOD CELLS

选用金黄地鼠，从足背静脉注射大分子右旋糖酐的方法，复制以血 细胞聚集为基础的微循环障碍动物模型，然后注射“复方脑桂１号”和“维脑路通”。 通过显微电视录像系统将图像放大约８００倍，观测体内与体外血细胞聚集－解聚 动态变化过程，并作定性定量分析．纶果表明：“复方脑栓１号”对体内外血细胞有 明显的解聚作用（治疗作用）和抑制血细胞的聚集效应（预防作用）且均优于常用 药“维脑路通”．

An experimental animal model of microcirculatory disturbance was produced by dorsal intravenous injection of large molecule weight dextran in 20 Golden hamsters. The animal disturbance models are based on aggregation of red blood cell (RBC). They were respectively injected 'Fufang Naoshuan-1' and 'Weinaolutong'. The images of RBC aggregation were magnified by 800 with intravital videomicroscopic methods and videomicrorheometar. The images of RBC aggregation-disaggregation changes were observed in Vivo and In vitro. Through qualitative and quantitative analysis, the results showed 'Fufang Naoshuan -1' could be significantly useful in the disaggregation of RBC, and inhibit the aggregation of RBC in vivo and in virto.