白塞氏病辨证分型与免疫功能关系

Relationship of Differentiating Symptoms of Bchcet′s Disease and Immune Function

了解白塞氏病（ＢＤ）不同证型与免疫功能的关系。方法：将１８名ＢＤ患者按辨证理论分为湿热壅盛型（１０例）和肝肾阴虚型（８例）两组，设健康对照组，采用细胞膜表面ＩｇＦｃＲ＋受体分类法及单向琼脂扩散法对各组受试者进行免疫活性细胞（Ｔ淋巴细胞Ｔｔ、ＴＨ、ＴＳ和Ｂ淋巴细胞）测定及免疫球蛋白测定。结果：两组ＢＤ患者Ｔｔ、ＴＨ明显减少，ＩｇＡ、ＩｇＭ升高（Ｐ＜０００１，Ｐ＜００１或Ｐ＜００５），其中湿热壅盛型上述指标的改变比肝肾阴虚型更为明显（除ＩｇＭ外），受检ＢＤ患者ＴＨ／ＴＳ值均低于正常对照者，而以湿热壅盛型ＴＨ／ＴＳ值下降更为显著（Ｐ＜００５）。结论：湿热壅盛型和肝肾阴虚型ＢＤ患者在免疫功能异常方面存在差异，湿热壅盛型存在更加明显的细胞免疫缺陷和体液免疫调节紊乱。

Objective:To Observe the relationship f differentiating symptoms of Behcet′s disease (BD) and cellular and humoral immunity.Methods:Eighteen BD cases were divided into hypropyrosis retension grorp (Ⅰ) and dificiency of liver and kidney group (Ⅱ).With the techniques of cell surface IgFc receptor classification and single agar diffusion test,a variety of immunocompetent cells (Tt,TH,Ts and B cell)and immunoglobalins were categorized and assayed for group Ⅰ and group Ⅱ.Results:Significant decrease of Tt,TH (P<001 or 001) and increase of IgA and IgM (P〈001 or 005) were found in group Ⅰ and Ⅱ.The changes in group Ⅰ,excluding IgM,were more significant than those in group Ⅱ.The TH/TS values were lower than normal in group Ⅰ and Ⅱ.In contrast to group Ⅱ more significant decrease of Th/Ts were found in group Ⅰ.Conclusions:Immune functions were important roles for differentiating symptoms of BD.