血小板激活因子对人胚肺成纤维细胞生长的调节

Promoting Pulmonary Embryo of Human Fibroblast Growth Activity Produced by Platelet Activating Factor

我们曾检测了矽肺患者体内ＰＡＦ（血小板激活因子）的含量，结果表明矽肺病人血浆ＰＡＦ含量升高，提示ＰＡＦ参与矽肺的发生发展。为了解ＰＡＦ对ＦＢ（成纤维细胞）的生长、调节作用，本研究采用体外细胞学研究的方法研究ＰＡＦ对ＦＢ生长的影响，结果表明ＰＡＦ能有效地促进ＦＢ的增殖、它与其它细胞因子如ＴＮＦ、ＩＬ－１等井同调控ＦＢ的增殖和胶原的生成。

The plasma levels of PAF were determined in silicosis patients. The result showed that the plasma PAF was increased in silicosis patients,and PAF could be involved in the patho- physiological changes in silicosis. in order to understand that FB growth activity produced by PAF,this research was determined promoting pulmonary embryo of human FB growth activi- ty by PAF with research of cytology in vitro. The result indicated that the promoting FB growth activity was higher proliferation by PAF. PAF could be regulated proliferation of FB and take shape of collagen with many other cytokines,for example TNF.IL- 1 et al.