慢性肝病患者血清TGFβ1、Ⅰ-C、Ⅲ-C水平及其与肝纤维化的关系

THE MEASUREMENT OF SERUM TGFβ_1,, Ⅰ-C AND Ⅲ -C IN PATIENTS WITH CHR0NIC LIVER DISEASES AND THE RELATIONSHIP BETWEEN THESE INDICES AND HEPATIC FIBROSIS

应用酶免疫技术对118例慢性肝炎、肝硬化患者进行血清转化生长因子β1（TGFβ1）、Ⅰ、Ⅲ型胶原（Ⅰ－C、Ⅲ－C）含量测定，分析三者与肝功能指标间相关关系。结果表明，患者血清TGFβ、Ⅰ、Ⅲ型胶原含量均高于正常对照组，且随慢迁肝→慢活肝→肝硬化逐渐递增，组间差异显著。血清TGFβ1与Ⅰ－C、Ⅲ-C、谷丙转氨酶呈正相关，与白／球比值、血清总胆红素不相关。提示TGFβ1可能是一种很有前途的肝纤维化血清学标志物，与Ⅰ、Ⅲ型胶原的联合检测可能有重要的临床意义。

The serum TGF3,, I -C and, -Cconcentrations were determined by ELISA in ll8patients with chronic hepatitis and cirrh0sis, rela-tionships between TGF5,, I -C and, -C and sever-al indices renecting liver function were analyzed.The result sh0wed that the patients with HC hadsignificantly higher serum TGF9,, l -C and, -Clevels than those with CAH, who had significantlythose with CPH. The patients with NC had l0werserum TGF9,, I -C and 1 -C c0ncentrati0ns.Serum TGF5, levels had a p0sitive c0rrelati0n withI -C, 1 -C, ALT and n0 significant c0rrelationwith A/G. STB. These suggest that TGF8, mightbe a pr0mising serum mark f0r hepatic fibr0sis, theassay 0f serum TGFP, and I -C would be valuablefor clinic.