甲状腺癌和雌、孕激素受体的研究

STUDY OF ESTROGEN AND PROGESTERONE RECEPTOR IN THYROID CANCER

利用酶联亲和组化法检测80例甲状腺良恶性肿瘤雌、孕激素受体（ER，PR）。结果显示：ER，PR阳性率与肿瘤良恶性、分化程度、性别有关。提示：ER，PR可作为甲状腺癌的一个生物学标记，有助于预后判断。ER是影响女性甲状腺癌发病率的一个重要因素，ER，PR阳性细胞可为进一步研究雌、孕激素对甲状腺肿瘤的作用机制提供一个线索。

Estrogen receptor (ER ) and progesterone receptor(PR) were rneasured using enzymelinked histochemical technique in 80 specimens of thyroid neoplasma. Results of this study showed that sex. nature and grade of neoplasma were the factors influencing the positive rates of ER and PR.It's indicated that detected ER and PR can be used as biological makers, in aid of the choice of clinicalprognosis, endocrinotherapy and the judgtnent of patients. Observed sex differences regarding thyroid tumor incidence may reflect the higher ER and PR positive rates of females. The ER-Positive tumor cell lines are useful for studying the direct effect of estroqen on thvroid tumors.