自动快速广谱药物检测系统在急性药物中毒昏迷患者诊断中的应用

Application of an Automated Rapid Emergency Drug Identification System in Diagnosing the Coma Patients of Acute Drug Poisoning

目的评价自动快速广谱药物检测系统(REMEDi HS)在急性药物中毒昏迷患者诊断中的价值。方法用REMEDi HS分析630例急性药物中毒但不能确定毒物的昏迷患者血液、尿液及胃液中的药物成分。结果630例患者的检测结果中,药物检出率胃液>尿液>血液;中毒频率较高的前5类药物分别是:抗精神病药、苯丙胺类兴奋剂、阿片类毒品、三环类抗抑郁药、苯二氮类镇静催眠药;单药检出率前10名的药物是:氯氮平、西咪替丁、利多卡因、苯丙胺、美沙酮、苯海拉明、甲基苯丙胺、氯丙嗪、咖啡因、地西泮。结论REMEDi HS能较好地对急性药物中毒昏迷患者体内的药物成分进行快速定性分析,为救治患者提供实验室依据。

Objective To estimate the value of automated rapid emergency drug identification system （REMEDi HS） in diagnosing the coma patients of acute drug poisoning. Methods The samples of serum, urine and gastric juice from the 630 coma patients of acute drug poisoning for unknown causes were analyzed with REMEDi HS. Results The drug detection rates of the three samples were in declining order of gastric juice, urine and serum. The most frequently encountered five kinds of drugs were anti-psychotics, phenamine stimulant, opioid analgesics,tricyclic anti-depressant and benzodiazepines. Clozapine,cimetidine,lidocaine,phenamine,methadone,benzhydamine,amphedroxyn, chlorderazin, caffeine and diazepam were the ten drugs of highest frequency identified. Conclusion REMEDi HS can pmvide rapid qualitative analyses of the drugs in coma patients of acute drug poisoning and the lab proofs for the correct diagnoses.