摘要
采用随机双盲对照试验比较国产尼索地平和尼群地平片对60例轻、中度原发性高血压的疗效和安全性.经过10d的安慰剂清洗期后,入选患者随机接受尼索地平或尼群地平10mg,bid治疗共6wk.结果;尼索地平治疗组收缩压和舒张压分别(157.00±13.66)和(103.04±4.60)mmHg[(20.93±1.82)和(13.74±0.61)kPa]降至(139.00±13.34)和(87.71士6.81)mmHg[(18.53±1.78)和(11.69±0.91)kPa],收缩压和舒张压降压幅度分别达11.46%和14.88%;尼群地平组收缩压和舒张压分别从(157.31±12.80)和(101.86±4.52)mmHg[(20,97±1.71)和(13.58±0 60)kPa]降至(141.52±10.25)和(91.66±7.05)mmHg[(18.87±1.37)和(12.22±0.94)kPa],收缩压和舒张压降压幅度分别为10.04%和10.01%.两组中不良反应均多为轻度且呈一过性.提示国产尼索地平片和尼群地平片10～20mg bid po能有效治疗轻、中度原发性高血压,并具有较好的安全性.
60 patients with mild to moderate essential hypertension were recruited into a randomized,double-blinded study to compare the efficacy and safety of nisoldipine and ni-trendipine. After a 10-day placebo run-in period, the patients were randomized to receive 10-20 mg twice daily treatment of either nisoldipine or nitrendipine for 6 weeks.Results. After the treatment of nisoldpine, systolic and diastolic blood pressure were reduced 11.46% and 14.88%,from (157.00±13.66)to (139.00±13.34)mmHg and from (103.04±4.60) to (101. 86±4. 52)mmHg,respectively. While,in the nitrendipine group, systolic and diastolic blood pressure was reduced 10.04% and 10. 01%, from (157.31±12.80) to (141.52±10.25)mmHg and from (102.14±4.89) to (91.66±7. 05)mmHg,respectively. Adverse events were mostly mild and transient in both groups.Conclusion. Treatment of 10-20 mg twice daily nisoldipine and nitrendipine are effective and well tolerated for patients with mild to moderate essential hypertension.
出处
《中国临床药学杂志》
CAS
1997年第4期144-147,共4页
Chinese Journal of Clinical Pharmacy
