枸橼酸克罗米酚治疗少弱精子症不育578例临床报告

The use of clomiphene citrate in oligospermic infertility

本研究对少弱精子症患者５７８例采用每日口服克罗米酚５０ｍｇ作治疗观察。并以精液参数和其它临床资料与上述患者相当的志愿者３０例，服安慰剂作为对照，每３个月为一疗程。用药前后检查精液及ＦＳＨ、ＬＨ、Ｔ，并于每一疗程后随访。结果服克罗米酚组妊娠２１７例，妊娠率３７．５％，精子密度及活动力改善２４２例，改善率４１．９％。对照组妊娠２例，妊娠率６．７％，精子参数改善５例，改善率１６．７％。经统计学处理，两组间妊娠率和精子参数改善率差异有显著意义（Ｐ＜０．０１）。妊娠和精子参数改善大多数（９０．８％）发生在第二、三疗程。本文认为克罗米酚是治疗少、弱精子症的有效药物。

From January 1989 to January 1995, 578 of randomized oligospermic patients were selected and were treated with clomiphene (50mg/d)against vitamin C 600mg every day and other 30 of patients with same semen parameters served as controlled group. for 3 months Serum FSH,LH,PRL,T and the semen analyses were monitored before and after treatment. In this randomized study, 217 pregnancies (37.5%) and 242 seminal parameters improvement (41.9%) were occurred in the clomiphene group, and in the placebo-controlled group were 2(6.7%) and 5(16.7%) respectively. Significant difference were noted between the two groups (P<0.01).