甲状腺乳头状癌CD44v6、VEGF-C的表达及临床意义

Expressions and Significance of CD44v6 and VEGF-C in Patients with Papillary Thyroid Carcinoma

目的探讨甲状腺乳头状癌(FTC)中CD44v6和VEGF-C的表达及意义。方法应用免疫组织化学SP法检测78例甲状腺乳头状癌和18例甲状腺良性肿瘤中CD44v6和VEGF-C蛋白的表达,并进行比较。结果甲状腺乳头状癌组织中CD44v6和VEGF-C的阳性表达明显高于良性病变(P<0.05);CD44v6和VEGF-C的表达与甲状腺乳头状癌浸润程度及淋巴结转移有相关性(P<0.05);二者在甲状腺乳头状癌组织中表达呈正相关(P<0.05)。结论CD44v6和VEGF-C可能作为甲状腺乳头状癌的肿瘤标志物之一;CD44v6和VEGF-C表达与甲状腺乳头状癌浸润程度、淋巴结转移相关,二者联合检测对判断甲状腺乳头状癌侵袭与转移具有一定意义。

Objective To study the significance of CD44v6 and VEGF- C expressions in patients with papillary thyroid carcinoma（PTC）. Methods Immunohistochemical SP method was used to detect the expressions of CD44v6 and VEGF - C in 72 cases with FIX2 and 18 cases with benign thyroid lesions; Using the mathod of statistics to compare clinical characteristics of PTC. Results The expression rate of CD44v6 and VEGF - C in PTC was significantly higher than that in benign thyroid lesions. There were correlation in the expression of CD44v6 and VEGF- C between the degree of infiltration and lymph node metastasis in PTC;There was signifi- candy positive correlation between the expression of CD44v6 and VEGF- C in PTC and were synergistic in action with one another. No correlation was found between age, sex and PTC. Conclusion CD44v6 and VEGF - C can be used as one of the markers of papillary thyroid carcinoma. The expression of CD44v6 and VEGF- C are correlated with the degree of infiltration and lymph node metastasis in PTC, which may be a significant parameters for determining invasiveness and metastasis of PTC.