CD44v6在非小细胞肺癌组织中的表达及其临床意义

Expression and Significance of CD44v6 in Non-small Cell Lung Cancers

目的研究CD44v6在非小细胞肺癌组织的表达及其临床意义。方法用免疫组织化学法检测CD44v6在55例非小细胞肺癌组织、癌旁组织及20例正常肺组织的表达,并分析其与肺癌分期、类型、淋巴结转移及术后3年和5年生存率之间的关系。结果CD44v6在肺癌组织中的表达显著高于癌旁组织,与临床病理分期(PTNM分期)成显著正相关,有淋巴结转移组显著高于无淋巴结转移组,与术后5年生存率成负相关。结论在非小细胞肺癌组织中的CD44v6高表达与肺癌的发生发展、淋巴结转移及预后有一定的关系。检测CD44v6在非小细胞肺癌组织中的表达,可作为判断非小细胞肺癌淋巴结转移潜能及预后的一个指标。

Objective To study the expression and significance of CD44v6 in non-small cell lung cancer （NSCLC）. Methods The expression of CD44v6 was detected by immunohistochemical method in 55 patients with NSCLC and 20 specimens of normal lung tissues. Its correlations with clinical stages, pathological types, metastatic states of lymph nodes and survival rate were studied. Results The expression of CD44v6 in tissues of NSCLC was significantly higher than that in paracancer. The rate of positive expression of CD44v6 had a significant correlation with PTNM and lymph node metastasis in tissues of NSCLC. The rate of positive expression of CD44v6 had negative correlation with the to survival rate. Conclusion The high expression of CD44v6 may have a correlation with the development and lymph node metastasis and prognosis of NSCLC. The expression of CD44v6 may be taken as a guideline for predicting the potentiality of lymph node metastasis and prognosis in patients of NSCLC.