神经生长因子在涎腺腺样囊性癌中的表达及其临床意义

The Expression and Clinical Significance of NGF in Salivary Adenoid Cystic Carcinoma

目的探讨神经生长因子(NGF)在涎腺腺样囊性癌(ACC)不同病理组织学类型中的表达及其与嗜神经性的关系和临床意义。方法采用免疫组织化学S-P法,检测NGF在43例涎腺腺样囊性癌组织中的表达,并分析它与涎腺腺样囊性癌病理组织学类型和嗜神经性的关系及其与生存率的关系。结果NGF在ACC不同病理组织学类型中的表达差异有统计学意义(P<0.05);NGF在嗜神经现象组与无嗜神经现象组间的阳性表达差异也有统计学意义(P<0.05)。结论NGF在ACC中的表达强度与ACC病理组织学类型及嗜神经性有一定相关性,可作为该肿瘤预后判断的指标。

Objective To study the expression and relationship of nerve growth factor（NGF） in the pathological types and perineural invasion of salivary adenoid cystic carcinoma （ACC） and its clinical significance. Methods The expressions of NGF was detected by S-P immunohistochemical method in 43 cases of human salivary adenoid cystic carcinoma tissues.Their relationships with the clinical pathological types,perineural invasion and survival were also analyzed. Results The positive expression of NGF had notably statistical significance with clinical pathological types of ACC （P〈0.05）. The expressions of NGF in 23 cases with perineural invasion was significantly higher than that in 20 cases without perineural invasion （P〈0.05）. Conclusion In human ACC, the expressions of NGF were closely correlated with clinical pathological types and perineural invasion of ACC. Detection of NGF protein may have protential effects on the prognosis of ACC.