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控制血糖对多发伤合并颅脑外伤患者血清IL-6、IL-10的影响

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摘要 目的研究控制血糖对多发伤合并严重颅脑外伤患者血清细胞因子及急性生理、慢性健康评估(APACHEⅡ评分系统)和Glasgow昏迷评分(GCS)的影响。方法患者随机分为胰岛素强化治疗组和常规胰岛素治疗组,于入重症监护病房(ICU)后用ELISA法测定血清中促炎因子白细胞介素-6(IL-6)和抗炎因子白细胞介素-10(IL-10)的浓度,同时评估患者的APACHEⅡ评分和GCS。结果胰岛素强化治疗显著降低血清中IL-6浓度和增加IL-10浓度,还明显降低患者的APACHEⅡ评分和提高GCS,差异均有统计学意义(均P<0.05或<0.01)。结论胰岛素强化治疗降低血清中促炎细胞因子,还能增加抗炎细胞因子,并使病情有所好转。
出处 《苏州大学学报(医学版)》 CAS 北大核心 2008年第2期294-295,共2页 Suzhou University Journal of Medical Science
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