抑郁症静息态大脑双侧杏仁核的功能连接

Amygdalar interhemispheric functional connectivity in depression:a resting-state fMRI study

目的:探讨静息态下抑郁症患者大脑半球双侧杏仁核的功能连接特点,了解杏仁核及其功能相关脑区在抑郁症病理机制中的作用。方法:11例首次发作的重性抑郁症患者与11例性别、年龄、受教育程度均与患者相匹配的正常人完成静息态功能性磁共振成像(fMRI)扫描。利用Pearson相关分析方法分析受试者大脑双侧的杏仁核功能连接强度,并利用双样本t检验做组间对比,设P<0.05为差异具有显著性。结果:静息态下,两组双侧杏仁核均具有明显的功能连接(P<0.05),而抑郁症组较对照组的功能连接明显减低(P=0.025)。结论:静息态下抑郁症组双侧杏仁核功能连接存在异常,这可能与抑郁症患者杏仁核异常及杏仁核与其他情感调节相关脑区的协调异常有关。

Objective ： To explore the feature of amygdalar interhemispheric functional connectivity in the patients with major depressive disorders（MDDs） during resting state and thereby to explore the role of amygdalar and amygdalar-related regions in the psychopathology of depression. Method：The resting-state function magnetic resonance imaging （fMRI） scans were performed in 11 first-episode patients with MDDs and 11 gender, age, and education matched healthy controls. Pearson correlation analysis was used to measure the amygdalar interhemispheric functional connectivity in each subject and two sample test was used to analyse the difference of correlation coefficient between two groups. P 〈 0.05 was considered to show significant difference between two groups. Results ：The depressed group and healthy controls revealed significant amygdalar interhemispheric functional connectivity （ P 〈 0.05 ）. In comparison with healthy control group, the depressed group showed significantly decreased amygdalar interhemispheric functional connectivity during resting state（ P = 0.025 ）. Conclusion：The result indicated decreased amygdalar interhemispheric functional connectivity may exist in depression during resting state and it may be due to the abnormality of amygdalar and the abnormality of coordination between amygdalar and other emotion-related regions.