芦荟联合维生素E预防放射性皮肤损伤的效果观察

The effects of the combination of aloe and vitamin E in preventing radioactive skin injury

目的探讨芦荟、维生素E联合外用对放疗时患者皮肤的保护效果。方法将应用直线加速器首次接受放疗的138例恶性肿瘤患者随机分为预防组（n=70）及对照组（n=68），预防组于每次放疗前将新鲜芦荟汁均匀涂在患者照射野皮肤，待自然干燥后再行放疗，每次放疗结束用冷开水清洁照射野皮肤，涂适量维生素E。出现皮肤损伤后可增加局部用药（芦荟，维生素E）次数；对照组照射野皮肤不采用保护措施，出现皮肤损伤后局部涂氟哌酸或用金因肽外喷。对两组患者照射野皮肤按RTOG急性放射损伤分级标准每日进行评价至疗程结束。结果预防组放射性皮肤损伤发生率明显低于对照组，损伤程度明显轻于对照组，损伤发生时间比对照组明显推迟，差异均有统计学意义。结论芦荟与维生素E联合局部给药，对恶性肿瘤放射性皮肤损伤有较好的预防和控制效果。

Objective To observe the effects of the combination of aloe and vitamin E in the prevention of irradiation-induced acute skin injury. Methods 138 cases with malignant tumors who received first radiation under linear accelerator were randomized into prevention group （n = 70） and control group （n = 68）. Among the prevention group, patients were applied with fresh aloe fluids on radiation sites until they were dry before radiation. After each radiation, the radiation sties were cleaned with cool boiled water and applied with vitamin E. If skin lesion occurred, times of local use of aloe and vitamin E could be increased. In the control group, no skin protection measures were used. If skin lesion occurred, local use of norfloxacin or Genetime spray （recombinant human epidermal growth factor derivative）. RTOG scores were used to assess skin integrity of radiation sites in both groups everyday till all radiations were completed. Results Skin reaction rate and grade in prevention group were significantly less than those in the control group and the time occurring skin lesion in prevention group was significantly delayed （ P 〈 0. 05 ）. Conclusions The combination of aloe and vitamin E is effective in preventing and controlling irradiation-induced skin injury.