Heighten the Study on Factor Seven Activating Protease

Recent studies have showed that factor seven activa-ting protease(FSAP)is a novel serine protease in humanplasma.Immunoreactivity for FSAP has been observed invascular endothelial cells,epithelial cells and macropha-ges but FSAP-specific mRNA expression only exists inthe former two cells.FSAP has three epidermal growthfactor(EGF)domains,a kringle domain and a serineprotease domain.It circulates in the plasma as an inac-tive zymogen and undergoes autoactivation from a

Recent studies have showed that factor seven activating protease （FSAP） is a novel serine protease in human plasma. Immunoreactivity for FSAP has been observed in vascular endothelial cells, epithelial cells and macrophages but FSAP-specific mRNA expression only exists in the former two cells. FSAP has three epidermal growth factor （EGF） domains, a kringle domain and a serine protease domain. It circulates in the plasma as an inactive zymogen and undergoes autoactivation from a single chain to two chain enzyme form in the presence of polya-nionic macromolecules such as heparin and RNA.