VEGF、CD 62P和PMA与SLE患者易栓状态关系研究

Research on the Relationship of VEGF,CD 62p and Platelet-Monocyte Aggregation(PMA)in Patients with Systemic Lupus Erythematosus

目的观察系统性红斑狼疮(SLE)患者血管新生、血小板活化因子的临床意义。方法用流式细胞术测定血小板CD 62P、血小板-单核细胞聚合体(PMA),ELISA法测定血管内皮细胞生长因子(VEGF)。结果SLE活动期VEGF、血小板及炎症细胞的活化水平明显增高(P<0.05),稳定期该类闪子已基本恢复正常水平(P>0.05)。SLE患者治疗后VEGF、血小板及炎症细胞的活化程度抑制,与治疗前相比有显著差异(P<0.05)。结论SLE患者处于血栓前状态,易于发生动静脉血栓事件,早期发现临床征象可以及时干预治疗,改善预后。

Objective To investigate the significance of vascular endothelial growth factor （VEGF） and platelet activation factor in patients with systemic lupus erythematosus. Methods CD 62p and platelet- monocyte aggregation （PMA）were detected using flow cytometry,VEGF was detected by enzyme-linked immunosorbent assay （ELISA） . Results In patients with systemic lupus erythematosus, the level of VEGF and platelet activation factor is stepped up in active stage （ P 〈 0.05 ）, these factors were nearly normal in stable phase （P 〉 0.05 ）, these factors dramatically stepped down after theraping （ P 〈 0.05 ）. Conclusions Patients with systemic lupus erythematosus were in prethrombotic state , they may be useful for diagnosis and early treatment.