消炎利胆片对胆汁内细菌抑制作用的临床研究

Clinical Study of Antimicrobial Effects of "Xiaoyanlidan Tablets"

目的观察消炎利胆片对胆总管探查术后患者T管胆汁细菌数量的影响。方法将46例进行胆道探查术的患者随机分为对照组(23例)和治疗组(23例);术后两组均用抗生素3天,治疗组在术后第4天始加服消炎利胆片(5片,tid),连续服用5 d。采集两组患者术后0、6、8天的胆汁作细菌培养,比较两组患者用药后的菌谱及带菌时间的变化,观察胆汁量的变化。结果两组患者在术后第8天胆汁中细菌培养阳性率较手术日明显减少(P<0.05,P<0.01),术后第8天治疗组T管胆汁中细菌培养阳性率较对照组减少更明显(P<0.01);两组胆汁培养的菌谱无改变。结论消炎利胆片可以明显减少术后T管胆汁中的细菌数量以及缩短胆汁带菌的时间,可能与其利胆及抗菌作用有关。

Objective To study the antimicrobial effects of ＂Xiaoyanlidan Tablets＂ on T tube bile in common bile duct exploration patients. Methods 46 patients were randomized into two groups： the xiaoyanlidan group （n=23） and the non-xiaoyanlidan group （n=23）. All of the patients in the xiaoyanlidan group were administered with ＂Xiaoyanlidan Tablets＂ for two weeks from the 4th day after operation. We performed the bacterial culture of bile in all of the patients from both groups on the day 0, 6 and 8 postoperatively and compared the differences of culture results between the groups, the bile volume drained by T tube per day were also measured. Results The bacterial positive ratio on day 8 was lower than that on the day 0 in all of the patients, but patients administered with ＂Xiaoyanlidan Tablets＂ for 5 days showed a more rapid bile bacterial clearance speed than non-xiaoyanlidan patients. Conclusion The bacterial positive ratio and the bacterial clearance time were significantly reduced by ＂Tiaoyanlidan Tablets＂, which shows antimicrobial effects and bile wash effect in common bile duct exploration patients.