通关汤加味治疗良性前列腺增生及其对睾酮、雌二醇的影响

Effects of Modified "Tongguan Decoction" on Serum Testosterone and Estrogen of Benign Prostatic Hyperplasia

目的研究通关汤加味治疗良性前列腺增生(BPH)的临床疗效及作用机制。方法将112例患者随机分为治疗组和对照组各56例,对照组用保列治治疗,治疗组用通关汤加味治疗,两组疗程均为6个月。治疗前后分别评估国际前列腺症状评分(IPSS)、前列腺体积(PV)、最大尿流率(Qmax)、膀胱残余尿量(Ru),并测定外周血睾酮(T)、雌二醇(E2)水平变化情况。结果治疗组总有效率为94.64%,对照组为71.43%;组间疗效比较,差异有统计学意义(P<0.05)。治疗后治疗组IPSS、Ru、PV明显减少,Qmax增加,外周血E2水平升高(P<0.05,P<0.01);对照组IPSS、Ru明显减少,Qmax明显增加(P<0.05,P<0.01)。除外周血T水平外,治疗后组间其他指标比较,差异均有统计学意义(P<0.05,P<0.01)。结论通关汤加味治疗BPH临床疗效显著,其机制可能与明显增加外周血E2水平有关。

Objective To observe the clinical efficacy and mechanisms of modified ＂Tongguan Decoction＂ in the treatment of benign prostatic hyperplasia. Methods 112 patients were devided randomly into two groups： control group in which 56 cases were treated with proscar, and treatment group in which 56 cases were treted with modified ＂Tongguan Decoction＂. The clinical efficacy such as IPSS, PV, Qmax, Ru, serum testosterone（T） and estrogen （E2） were observed. Results The total effective rate was 94.64% in treatment group and 71.43% in control group （P 〈 0.05）. After treatment in treatment group, IPSS, Ru and PV were significantly decreased and Qmax and E2 were significantly increased （P〈 0.05, P〈 0.01）; in control group, IPSS and Ru were significantly decreased, the Qmax E2 were significantly increased （P〈 0.05, P〈 0.01）. Conclusion Modified ＂Tongguan Decoction＂ is quite effective for benign prostatic hyperplasia possibly by significantly increasing serum E2.