胃癌发生与胃幽门螺杆菌感染关系的研究

Relationship between Infection of Helicobacter Pylori and Carcinoma of Stomach

采用ＰＣＲ技术对５６例胃癌、６０例慢性胃炎及１２例正常胃粘膜组织做了ＨＰ检测，结果，胃炎中ＨＰ检出率９３．３３％，胃癌组织检出率４１．０７％，正常胃粘膜中仅为１６．６７％，提示胃炎的发生与ＨＰ感染明显相关，胃癌的发生与ＨＰ可能有一定的关系。从胃癌发生部位看，贲门部ＨＰ感染率低（９．５２％），胃窦部及小弯区ＨＰ感染率高（６８．０％、３７．５％）。从病理分型角度看，分化型（腺样型）癌组织ＨＰ感染率较高（５５．８８％），低分化型（弥漫型）癌组织较低（２０％）。

56 cases of carcinoma of stomach was checked for Hilicobacter Pylori (HP) by the technique of polymerase chain reaction to compare with 60 cases of gastritis and 12 cases of normal gastric tissues. The infection rates of HP were 41 07%,93 3% and 16 67% respectively.The infection rates of carcinomas was much lower at the upper of stomach(9.52%),68% at middle and 37 5% at the pats. The infection rates of differentiated carcinomas was 55 8% but poorly differentiated carcinomas was 20 0% .