三唑酮的合成工艺

Synthesis of 1,2,4-triazolo[4,3-a]pyridin-3(2H)-one

以2-氯吡啶为原料经水合肼取代,再和尿素环化合成标题化合物,条件温和,操作简单,收率较高。在取代过程中未反应完的原料可循环套用,适合工业化生产。

1,2,4-Triazolo[4,3-a]pyridin-3（2H）-one was synthesized from 2-chloropyridine via substitution with hydrazine hydrate,followed by cyclocondensation with urea.The reaction was very moderate and easy to operate,with good yield.During the condensation reaction,the feedstock remaining after reaction can be recycled,and this synthesis route was suitable for the commercial production.