严重烧伤患者血液单核细胞体外产生白细胞介素-1量的变化及临床意义

Changes and its clinical significance in interleukin1 production by blood monocytes in vitro in severely burned patients

目的：检测严重烧伤患者伤后血液单核细胞体外产生白细胞介素１（ＩＬ１）量的变化，并结合内脏功能损害、多器官衰竭（ＭＯＦ）和严重全身感染的发生情况探讨其意义。方法：采用生物法检测２４例严重烧伤患者伤后不同时间单个器官功能损害患者、ＭＯＦ患者、局部感染患者和严重全身感染患者及３０例正常人单核细胞体外产生ＩＬＬ的量。结果：烧伤患者伤后单核细胞产生ＩＬ１的量减少，且病情越重，减少越多，在ＭＯＦ患者尤为明显；ＩＬ１产生量的变化与患者心、肝酶呈明显负相关。结论：ＩＬ１在严重烧伤患者内脏功能损害及ＭＯＦ的发生发展中起着重要作用。

Objective:To examine changes in interleukin1(IL1) production by blood monocytes in vitro,and to explore the pathogenesis of postburn multiple organ failure (MOF) in severely burned patients.Methods:A biological method was used to determine changes in IL1 production by blood monocytes in vi tro in 30 healthy volunteers and 24 severely burned patients.The study was carried out in patients with and without systemic infection and internal organ injury.Results:It was shown that there was obvious decrease of monocytic IL1 production in vitro in severely burned patients.As the severity of illness became worse,the IL1 production by blood monocytes was persistently reduced,especially in patients with MOF.Also,changes in IL1 production were negatively correlated with cardiac and hepatic enzymogram.Conclusions:IL1 may play an important role in the pathogenesis of internal organ injury or MOF in patients with severe burns.