狼疮性肾炎尿毒症可逆性的长期观察报告

Long-term survey on reversible uremia in patients with lupus nephritis

目的 探讨狼疮性肾炎尿毒症的可逆性。方法 在15年中,对37例狼疮性肾炎已开始进行透析的患者,给予积极的激素和环磷酰胺治疗。结果 83.8％的患者脱离了透析,停止透析的平均时间为40.6±21.5个月,停止透析半年以上的血肌酐值平均为179.36±88.24μmol/L。结论 需要透析的狼疮性肾炎患者,并不等于终末期肾病,在有适应症时,经积极治疗,肾衰有逆转的可能。

Objective In order to investigate the reversibility of uremia in patients with lupus nephritis(LN). Methods 37 uremic patients with IN who underwent dialysis were treated with a progressive protocol of combined glucocorticoid and cyclophosphamide (CTX) during the last 15 years. Results 83.8% of patients withdrawed from dialysis, with an average withdrawal period of 40.6 ±21.5 months, and with serum creatinine of 179.36 ±88.24 fjiaoVL at least half year after the withdrawal. Conclusion Uremic patients with LN who should be dialysed are not necessarily in end stage of their renal diseases, and those who are indicated for immunosuppressants and probable to be reversed should be treated properly and promptly.