肾提取液对大鼠庆大霉素肾毒性的防治作用研究

Protective Effects of Renal Extract on Gentamicin Nephrotoxicity in Rats

研究乳猪肾提取液对大鼠庆大霉素肾毒性的防治作用。新鲜乳猪肾经匀浆、超滤等处理得肾提取液。肌注庆大霉素100mg／（kg·d）×7d制成大鼠急性肾衰模型。制模同时及造模后分别ip肾提取液15mg／（kg·d），观察大鼠血清尿素氮（Bloodureanitrogen，BUN）、肌酐（Cr）及肾组织变化情况。实验结束时，预防组BUN为9．30±2．60mmol/L，Cr为125．00±26．60μmol／L；模型组BUN为12.80±2.45mmol／L，Cr为167．00±39．60μmol／L，P＜0．01。结果表明，肾提取液可明显减轻庆大霉素对大鼠的肾损害。

To investigate the effect of Renal Extract(RE) from porkets on gentamicin nephrotoxicityin rats. RE was isolated from porkling kidneys by mince and ultrafiltration. Administering Gentamicin100 mg/(kg·d) to rats by muscle for 7 days resulted in acute damage of kidney. At the same timeand after that, to inject RE 15 mg/ (kg· d) into abdomen. 'Bood urea nitrogen (BUN) of protectivegroup was 9. 30± 2. 60 mmol/L, Cr was 125. 00± 26. 60μmol/L, and BUN of model group was 12.80±2. 45 mmol/L, Cr was 167. 00±38. 60 μmol/L, P<0. 01. The result showed RE can protectkidney from Gentamicin.