口服抗凝药物实验室监测方法研究

Study of Labortory Survei Llance of Orol Anticogulant Drugs

对口服抗凝药物实验监测有关方法进行了探讨，介绍了一种简便易行较为敏感的实验方法“Hepato－Quick”。实验表明：此法所用试剂加入因子V和纤维蛋白原，大大提高了试验的特异性。所采用的稀释法，减少了非特异性抗凝物质对试验的干扰。该法突出的优点是可采用毛细血管血进行检测。比较表明：血浆法与毛细血管法有良的相关性（r＝0.9836，P＜0.001）。

Evaluation of a thromboplastin reagent (Hepato-Quick) for the control of oral anticoagulation serves as an example for the calculation of the so-called therapeutic range in comparison with already established test systems. The HepatoQuick system measures the coagulation defect introduced by oral anticoagulation with sufficient sensitivity both in plasma and capillary blood. Hepato-Quick system is particularly suited to discover congenital and acquired reductions in the level of factorsⅡ, Ⅶ andⅩ, as well as being suitable for controlling anticoagulant therapy with coumarins or phenylindandiones. The reagent is stabilized against changes in the amount of fibrinogen and factor V. Hepato-Quick test not only needs little equipment butalso the technique is simple. Little experience if required to obtain a reliable result, which is known in 2~ 3 minutes. The method can be applied to capillary blood as well to citrated blood samples.