血清超敏C反应蛋白的测定在冠心病早期诊断的临床意义

Clinical Significance of Detection of Serum High-Sensitivity C-reactive Protein in Early Diagnosis of Coronary Heart Disease

目的:探讨血清超敏C反应蛋白(hs-CRP)水平与冠心病的发生发展及预后的关系。方法:应用特定蛋白分析仪检测225例冠心病患者(其中包括心肌梗死患者117例,心绞痛患者108例)和正常对照组60例血清hs-CRP浓度。结果:各病例组血清hs-CRP水平明显高于正常对照组(P<0.01),冠心病各组间血清hs-CRP水平亦有显著性差异(P<0.01),且随冠心病病情的加重有逐步升高的趋势。结论:血清hs-CRP水平与冠心病的病情发展密切相关,可作为冠心病早期诊断和病情检测的指标。

Objective：To explore the effect of serum high-sensitivity C-Reactive protein on the development of coronary heart disease. Methods：The hs-CRP levels of 225 patients with CHD（including 117 cases of acute myocardial infarction and 108 of angina cordis）were tested. Results.. The serum level of hs-CRP was significantly higher in the patients with CHD than that in healthy controls （P〈0. 01） . The serum hs-CRP levels in several groups of the patients with CHD showed statistical difference （P〈0. 01）. Conclusion： The level of serum hs-CRP is positively correlated with the development of CHD. The serum hs-CRP can be regarded as an early prognostic indicator for CHD.