放射治疗对鼻咽癌患者细胞免疫功能的影响

The Effect of Radiotherapy on the Cellular Immunity in Patients with Nasopharyngeal Carcinoma

应用抗人淋巴细胞单克隆抗体检测32例鼻咽癌患者放疗前、后外周血T淋巴细胞亚群，并与12例非癌人群（对照组）进行对比。结果：鼻咽癌患者OKT3、OKT4及OKT4/OKT8值与对照组相比明显降低，OKT8值显著上升（P＜0．05）；放疗后OKT3、OKT4及OKT4/OKT8值进一步下降，OKT8进一步升高（P＜0．01）。提示鼻咽癌患者细胞免疫功能低下，放射治疗可进一步抑制鼻咽癌患者的细胞免疫功能。

The T-lymphocyte subsets of 32 patients with nasopharyngeal carcinoma were inspected before and after radiotherapy using monoclonal antibody technique. The results showed that the percentages of OKT3、OKT4/OKT8 ratio were markedly decreased and OKT8 was markedly increased(P<0.05) in patients with nasopharyngeal carcinoma as compared with normal persons.After radiotherapy the percentages of OKT3、OKT4 and OKT4/OKT8 ratio decreased further, OKT8 increased further(P<0.01). These data proved that the cellular immunity in patients with nasopharyngeal carcinoma was deficient, the radiothera-py could markedly suppress the patients' cellular immunity.