有机铋化学近十年的研究进展

Organobismuth Chemistry in the Past Decade

铋及其化合物具有相对价廉、低毒性和低放射性等特点,已应用于医药、催化、化妆品和电子技术等领域。本文回顾了近10多年来有机铋化学的研究状况,主要从以下4个方面进行综述:(1)新型有机铋化合物的合成途径与结构特征;(2)有机铋化合物作为交联偶合、氧化、芳基化和其它反应的试剂;(3)作为催化剂;(4)作为生物医药用于溃疡、肿瘤和放射治疗等。文中着重从分子水平阐述了新型有机铋化合物的结构与其化学和生物活性之间的关系。此外,还介绍了有机铋化学研究领域的不足和今后的发展趋势。

Organobismuth chemistry is becoming more attractive since Bi is relatively low in price, toxicity and radioactivity, and many organobismuth compounds have found applications in medicine, catalysis, cosmetic, electronic technology, etc. Especially, it has undergone great changes in the past decade, and the research achievements are worthy of being summarized. This review on organobismuth chemistry is carried out as the following four aspects： （1） the molecular structure characteristics and synthesis of new organobismuth compounds; （2） as reagents for cross-coupling, oxidation, arylation, and other reactions; （3） as catalysts for organic synthesis; （4） as medicines for the treatment of ulcers, anti-tumor and radio-therapy, etc. The present review is emphasized on making a systematic summary on the relationship between the structure and chemical and biochemical activity of new organobismuth compounds from a viewpoint of molecular level. Finally, the scarcities and the future developing perspectives on organobismuth chemistry are also presented.