摘要
采用免疫组织化学SABC（链霉亲合素-生物素化过氧化物酶反应）方法，检测了32例胆管癌及3例胆管腺瘤组织中p53蛋白的表达状况。结果：前者p53蛋白的表达率为30％，后者均阴性；p53蛋白表达与癌细胞组织学类型、淋巴结转移及肿瘤部位均无相关性。本实验结果提示：p53蛋白参与了胆管癌的演变，但有关在胆管癌中具体的临床意义有待进一步研究。
The expression of p53 was Studied in tissue of thirty cases of biliary tract adenocarcinoma and threecases of biliary adenoma by SABC immunohistochemistry method. It revealed that 30% of the former cases was positivestain and all negative in the latter. No relationship was found between the p53 expression and the location, tissue typeand lymph node metastasis of the biliary tract adenocarcinoma.
关键词
抑癌基因
P53蛋白
胆管癌
免疫组化
Tumor-suppressor gene ,p53 expression, Biliary carcinoma, Immunohistochemistry
