摘要
为探讨梗阻性黄疸和胆囊结石患者全身和门静脉的血流动力学变化及消炎痛的调节作用，作者将73例梗阻性黄疸患者（A组）分为＜60岁非消炎痛组（A1组）、消炎痛术前组（A2组）、消炎痛术后组（A3组）和老年梗阻组（A6组），检测其全身和门静脉血流动力学变化，并与胆囊结石（B组）患者比较。结果：梗阻性黄疸各亚组每搏量、心输出量和心脏指数均显著高于B组（P＜0．01）；平均动脉压、周围血管阻力和门脉血流显著低于B组（P＜0．01）；A2、A3两组与其余各亚组比较，其平均动脉压、周围血管阻力和门脉血流虽有显著改善，但与B组比较仍有极显著性差异（P＜0．01）。提示消炎痛有改善梗阻性黄疸患者循环功能、门脉血流和肝功能的作用。
Hemodynamic changes of systemic and portal vein flow and regulation of indomethacin have beenStudied in 73 patients with obstructive jaundice(group A)and 39 cases with simple gallbladder stones(guoup B). Ob-strutive jaundice was subgrouped into group A1(no-indomethacin administration), group A2(pre-operative administra-tion of indomethacin), group A3(post-operative administration of indomethacin),and group A6(senile obstructive jaun-dice). of them group A1 was subgrouped into group A4(malignant obstruction)and group A5(benign obstruction)again.The results showed that the stroke volum(SV),cardiac output(CO)and cardac index(CI)were higher in each group ofobstructive jaundice than those in group B(P<0.01),and the mean artery pressure (MAP), stroke vessel resostance(SVR)and portal vein blood flow(PVF)were lower in each group of obstructive jaundice than those in group B(P <0.01) .The MAP,SVR and PVF in group A2 and group A3 showed better improvement than those in other subgroups,but as compared with group B there were significant differences (P < 0.01) .The authors consider that indomethacincan improve the circulation function, PVF and liver function in patients with obstructive jaundice.
