冠心病患者血清高敏C-反应蛋白和β2-微球蛋白水平及其相关性研究

Correlation between Serum Concentrations of High-sensitivity C-reactive Protein and of β_2-microglobulin in Patients with Coronary Heart Disease

目的测定冠心病患者的血清高敏C-反应蛋白(hs-CRP)和β2-微球蛋白(β2-MG)水平,探讨二者与冠心病发病的关系及其相关性。方法测定134例冠心病患者和40例冠脉造影正常者的血清hs-CRP及β2-MG水平并进行比较分析。结果急性心肌梗死(AMI)组、不稳定型心绞痛(UAP)组患者的hs-CRP、β2-MG水平与稳定型心绞痛(SAP)组、对照组的比较差异均有统计学意义(P<0.05);冠心病组及其亚组患者的hs-CRP水平和β2-MG水平呈正相关;AMI组、UAP组的hs-CRP、β2-MG异常高值发生率与SAP组的比较差异有统计学意义(P<0.05)。结论血清hs-CRP、β2-MG水平与冠状动脉病变程度可能相关,但具体机制尚不清楚,有待于进一步研究。

Objective To measure the levels of serum highsensitive C - reactive protein （ hs - CRP） andβ2 - micro- globulin （ β2 - MG） and to probe into their correlations with coronary heart disease （CHD）. Methods We measured and analyzed the serum levels of hs - CRP and β2 - MG in 134 patients with CHD and 40 normal Subjects . Results The levels of hs - CRP and β2 -MG were higher in acute myocardial infarction （AMI） group and unstable angina pectoris （UAP） group than in stable angina pectoris （SAP） group （ P 〈 0.05 ） ; hs - CRP was positively correlated with β2 - MG in CHD group and its subgroups; abnormally high value mainly occurred in AMI and UAP patients, whose positive rate was extremely remarkable. Conclusion Acute inflammatory process exists in the pathogenesis of CHD, and the two indexes might be consistent in disease course. Joint detection of hs - CRP and β2 - MG may be helpful when assessing risk of CAD. β2 - MG and hs - CRP have a close correlation with formation and development of CHD, especially with formation and （or） rupture and thrombosis of coronary artery sclerosis plaque.