变应性接触性皮炎动物模型的研究进展

Advance in the research of allergic contact dermatitis animal model

变应性接触性皮炎(ACD)是迟发型变态反应引起的炎症性皮肤病,涉及多种炎症介质和瘙痒介质。ACD的发生机制及其免疫反应机制在国内外已有较多的研究,但有关ACD伴发的瘙痒机制研究甚少,瘙痒介质也不明确。评价ACD的方法有多种,可归纳为炎症评价和瘙痒评价。目前公认的被用于评价实验动物瘙痒程度和作为临床观察瘙痒的客观指标为动物的搔抓行为。

Allergic contact dermatitis （ACD） is an inflammatory dermatologic disease induced by delayed type allergy. It refers to many kinds of mediators of inflammation and itch. There are many researches about the mechanism of development and immunological reaction of ACD, but there is very few researches on the mechanism of itch that accompanied by ACD, and the mediators of itch are not clearly. There are many evaluation methods of ACD, which can be inducted as inflammation and itch. To date the generally accepted objective index used to evaluate degree of animal itch and to observe itch is scratching.