慢性阻塞性肺疾病的抗炎治疗进展

Advance in anti-inflammatory treatment of chronic obstructive pulmonary disease

在全世界范围内慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）是导致成人发病率及病死率的主要原因。各种炎症细胞和炎症介质参与了COPD的发生发展，因此可能成为COPD的治疗靶点。现将糖皮质激素、细胞信号抑制剂、白三烯B4对抗物、趋化因子抑制剂、细胞因子及其调节剂和黏附分子抑制剂在COPD抗炎治疗中的应用作一综述。

Chronic obstructive pulmonary disease（COPD） is a leading cause of morbidity and mortality in adults worldwide. Many inflammatory cells and inflammatory mediators are involved in the development of COPD, they could become the targets in the treatment of COPD. The paper is to review advance of corticosteroids, the cell signal inhibitor, leukotriene B4 antagonists,chemokine inhibitors, cytokine and regulate agents and adhesion molecule inhibitors in the anti-inflammatory treatment of COPD .