糖克煎剂对2型糖尿病模型大鼠胰岛素抵抗的影响

Effect of TangKe Decoction on Insulin Resistance of Model Rats of Type Two Diabetes Mellitus

目的:研究糖克煎剂对2型糖尿病模型大鼠胰岛素抵抗的影响,探讨中医药对2型糖尿病的治疗作用。方法:用小剂量链脲佐菌素(STZ)加高热量饲料的方法复制出2型糖尿病大鼠模型,分别用中药复方糖克煎剂和罗格列酮作用于模型大鼠;检测实验大鼠的血糖、空腹胰岛素(FINS),用胰岛素敏感指数(ISI)衡量胰岛素抵抗程度。结果:模型组ISI明显低于正常对照组(P<0.05),治疗组ISI与模型组相比均明显提高(P<0.05)。结论:糖克煎剂可通过改善胰岛素抵抗而治疗2型糖尿病模型大鼠。

Objective： To study the effect of TangKe decoction on insulin resistance of model rats of type two diabetes mellitus, exploration the therapeutic action of Traditional Chinese Medicine on type two diabetes mellitus. Methods ： Rat model of insulin resistance of type two diabetes mellitus was duplicated by using small dose strepozotocln（STZ） and high caloric diet, and using TangKe decoction of compound chinese herbs and rosiglitazone acted on model rats individually. To detect blood glucose ,fasting insulin of experimental rat and measure its degree of insulin resistance by insulin sensitivity index（ISI）. Results： ISI of model group was significantly lower than control group（ P 〈 0.05 ）, ISI of therapufic groups were significantly increased over model group（ P 〈 0.05）. Conclusion： TangKe decoction can cure model rats of type two diabetes mellitus by improving theirs insulin resistance.