200例社区获得性金黄色葡萄球菌的耐药性分析

Analysis on drug-resistance of 200 strains of community-acquired staphylococcus aureus

目的探讨社区获得性金黄色葡萄球菌(CASA)的耐药性,为临床合理用药提供依据。方法对200株金黄色葡萄球菌,采用ATB Expression自动微生物分析仪及药敏专家系统进行鉴定和药敏试验。结果在200株CASA中,耐甲氧西林金黄色葡萄球菌(MRSA)的检出率为29.50%;耐药性统计结果,青霉素耐药率最高,为96.00%,其次是红霉素为63.00%,其它抗生素的耐药性均在33.00%以下,未见万古霉素、呋喃妥因、利萘唑胺和莫西沙星耐药菌株。结论社区获得性耐甲氧西林金黄色葡萄球(CA-MRSA)的耐药性不容忽视,CA-MRSA具有多重耐药性;CA-MRSA感染者首选治疗药物为万古霉素、呋喃妥因、利萘唑胺、莫西沙星、利福平和左氧氟沙星。

Objective To investigate the characteristics of drug-resistance of community-acquired staphylococcus aureus （CASA） so as to guide clinical doctors use antibiotic rationally. Methods 200 strains of staphylococcus aureus were collected. Microbial identification and antimicrobial susceptibility tests were done with ATB microbiological systems and its expert system. Results Meticillin-resistant staphylococcus aureus accounted for 29.50% of the 200 strains of CASA. In statistics of drug-resistance, penicillin took first place with a rate of 96,00%, followed by erythromycin （63.00%）. Other antibiotics were below 33.00%. No strains were found resistant to vancomycin, nitrofurantoin, linezolid, and moxifloxacin. Conclusions The drug-resistance of community- acquired meticillin-resistant staphylococcus aureus （CA-MRSA） should be thought of, CA-MRSA has multidrug- resistance. The choice of the patients treatment should be vancomycin, nitrofurantoin, linezolid, moxifloxacin, rifampin or levofloxacin.