不同降糖药物对2型糖尿病患者心电图QT离散度的影响

Effects of Different Hypoglycemic Drugs on QT Interval Dispersion in Patients with Type 2 Diabetes Mellitus

目的:探讨胰岛素、格列本脲、二甲双胍对2型糖尿病患者心电图QT离散度(QTd)的影响。方法:观察318例使用不同降糖药物治疗的2型糖尿病患者(胰岛素组129例,格列本脲组110例,二甲双胍组79例)及33例健康体检者(正常对照组)心电图QTd和校正QT离散度(QTcd)的组间差异。结果:格列本脲组心电图QTd和QTcd显著高于其他3组(P<0.05),胰岛素组QTd、QTcd显著高于二甲双胍组和正常对照组(P<0.05),二甲双胍组和正常对照组间QTd、QTcd无显著性差异(P>0.05)。结论:格列本脲和胰岛素可能会增加2型糖尿病患者心电图QTd、QTcd。

OBJECTIVE： To investigate the effects of different kinds of hypoglycemic drugs on the QT interval dispersion in patients with type 2 diabetes mellitus. METHODS： The differences of QT interval dispersion （QTd） and corrected QT interval dispersion （QTcd） in 318 patients with type 2 diabetes （of which, 129 were assigned to receive insulin, 110 glibenclamide and 79 metformin） and 33 healthy volunteers （normal control） were compared. RESULTS： The QTd and QTcd were all significantly higher in glibenclamide group than in the other three groups（P〈0.05）, and those indexes in insulin group were significantly higher than in metformin group or control group（P〈0.05）, but those indexes showed no significant difference between metforrnin group and control group（P 〉 0.05） . CONCLUSION： The results suggest that glibenclamide and insulin may increase the QTd and QTcd in patients with type 2 diabetes.