我院2007年药品不良反应报告分析

Retrospective Analysis of ADR Cases in Our Hospital in 2007

目的:分析我院药品不良反应(ADR)发生的特点与一般规律。方法:对我院2007年上报的209份ADR报告,按患者年龄、性别、给药途径、引起ADR的药品种类、涉及器官或系统以及临床表现等进行统计、分析。结果:静脉滴注较其他给药途径更易发生ADR(129例,占61.72%)。抗感染药引发ADR的比例最高(94例,占44.98%),其次为神经系统用药与心血管系统用药;喹诺酮类是引发ADR的主要抗感染药(35例,占37.23%),以左氧氟沙星为首。ADR的临床表现以皮疹、瘙痒等皮肤及其附件损害为主,其次为消化系统以及心血管系统损害。结论:应加强ADR监测意识,完善相关报告分析制度。

OBJECTIVE： To analyze the features and general patterns of adverse drug reactions （ADR） occurred in our hospital. METHODS： 209 ADR case reports collected in our hospital in 2007 were analyzed statistically in respect of patients＇ age and sex, route of administration, category of the drugs, organs and systems involved, and clinical manifestation of the ADRs. RESULTS： The ADR were more likely caused via intravenous dip （129 cases, 61.72%） . Anti- infectives had the highest proportion to induce ADR（94 cases, 44.98% ）, followed by nervous system drugs and cardiovascular system drugs. Quinolones were the leading anti- infective drugs causing ADR（35 cases, 37.23% ）, of which, Levofloxacin dominated the first place. The main presentation of the ADR was damage of skin and its appendages such as erythra and pruritus etc, followed by the lesions of digestive system and circulatory system. CONCLUSION： ADR monitoring awareness should be strengthened and the related ADR reporting system should be improved.