306例西咪替丁不良反应文献分析

Adverse Drug Reaction Induced by Cemetidine:Literature Analysis of 306 Cases

目的：探讨西咪替丁致不良反应的一般规律及特点。方法：对国内1983～2007年医药学术期刊报道的306例西咪替丁致不良反应的病例进行统计、分析。结果：西咪替丁所蠢的不良反应临床表现复杂多样，主要表现为中枢和外周神经系统损害（27．78％）、心血管系统损害（21．24％）、内分泌紊乱（8．82％）、血液系统损害（8．82％）等。结论：临床应重视西咪替丁所致的不良反应，特别应警惕再生障碍性贫血、心脏骤停、过敏性体克等的发生。

OBJECTIVE： To study the general pattern and characteristics of adverse drug reactions （ADR） induced by cimetidine. METHODS： A total of 306 ADR cases induced by cimetidine reported by domestic journals of 1983-2007 were analyzed statistically. RESULTS： The clinical manifestations of ADR induced by cimetidine were complicated and various and characterized by lesions of central nervous system （27.78%）, cardiovascular system （21.24%）, endocrine disturbance （8.82%） and hematological system （8.82%） etc. CONCLUSION： Great importance should be attached to the ADR induced by cimetidine to guard against the serious ADR such as aplastic anemia, cardiac arrest and allergic shock.