联合检测血清白细胞介素-6、铜蓝蛋白和甲胎蛋白对原发性肝癌的诊断价值

Determination of IL-6,ceruloplasmin and AFP in diagnosis of primary hepatic cancer

目的探讨联合检测血清白细胞介素-6、铜蓝蛋白和甲胎蛋白对原发性肝癌的诊断价值。方法对40例健康人、32例肝硬化患者和48例原发性肝癌患者分别采用ELISA和电化学发光免疫法检测血清白细胞介素-6和甲胎蛋白含量;采用特种蛋白仪检测铜蓝蛋白含量,之后进行结果分析。结果原发性肝癌患者中血清白细胞介素-6、铜蓝蛋白和甲胎蛋白阳性率分别为70.83%、66.67%和72.92%,显著高于对照组和肝硬化组(P<0.01)。结论与甲胎蛋白同时检测血清白细胞介素-6和铜蓝蛋白,对原发性肝癌的早期诊断具有重要价值。

Objective To study the association of serum ceruloplasmin, interleukin- 6 and AFP with the occurrence and development of primary liver cancer.Methods Serum intedeukin- 6 content was detemnined by ELISA,AFP by using Elecsys 2010 and serum cendopla.smin content, with a D ADE HERING special protein meter. Results In the patients with primary liver cancer, the positive rotes of serum interleuldn - 6, ceruloplasmin and AFP were 70.83% ,66.67%, and 72.92% ,significantly higher than those in normal control group and liver cirrhosis patient group （ P 〈0.01）.Conduslons It is very important for the early diagnosis of primary liver cancer to detennine serum IL- 6, ceruloplasmin and AFP simuhaneously.