胰腺癌术中射频消融治疗效果及安全性分析

Radiofrequency ablation in 23 patients with unresectable pancreatic carcinoma

目的评估术中射频消融治疗不能切除胰腺癌病例的有效性和安全性。方法对23例不能切除的胰腺癌病例实施术中射频消融,观察患者手术前后疼痛、黄疸、CA19-9、CEA、淀粉酶、影像学改变及术后并发症和生存率。结果术后87.05%的患者腹痛缓解,92%黄疸消退,CA19-9、CEA明显下降,淀粉酶一过性增高,术后CT示病灶血供减少。并发出血6例,胰瘘6例,均治愈出院。所有患者均获得随访,存活12个月以上12例,最长者已达42个月,生活质量较好。结论术中射频消融治疗不能切除的胰腺癌安全有效。

Objective To evaluate the efficacy and safety of radiofrequeney ablation（RFA） in the treatment of unresectable pancreatic carcinoma. Methods lntraoperative RFA was performed in 23 cases with unresectable advanced pancreatic carcinoma. Criteria including pain, jaundice, serum Ca19-9, CEA, amylase, complication,imaging,and survival rate of the patients were observed before and after RFA. Results Abdominal pain was alleviated in 87.05% of patients after RFA,jaundice subsided in 92% of patients who had icteric eyes,serum Cal9 - 9 and CEA declined markedly, and transient hyperamylasemia was observed among all patients. The CT imaging showed the partial necrosis in the tumors, to which blood supply was decreased. Bleeding occurred in 6 patients and minor pancreatic fistula in 6 after RFA, which were cured. All the patients were followed up, 12 out of 23 patients survived for more than 12 months, and 1 case survived for 42 months. Quality of life of patients was improved after RFA. Conclusions Intraoperative RFA is an effective and safe means for the treatment of unresectable pancreatic carcinoma.