内皮脂肪酶与原发性高血压的相关性研究

Research on Relation between Endothelial Lipase and Hypertension

目的检测内皮脂肪酶(EL)在原发性高血压病人血浆中的水平,探讨EL与高血压病的相关性。方法77例原发性高血压病人(高血压组)及34名健康对照者,分别进行病史采集,测量身高、体重、血压,并计算体重指数(BMI),监测血糖(FBG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、高敏C反应蛋白(hs-CRP)等指标。收集血标本,用酶联免疫吸附法检测血浆EL的水平,分析EL与高血压的相关性。结果对照组血浆EL浓度(338.7±51.0)ng/mL,高血压组EL浓度为(395.0±65.2)ng/mL,两组比较有统计学意义(P<0.05);高血压病人EL的表达与收缩压、舒张压呈正相关(r分别为0.17、0.08,P<0.05)。结论高血压病病人血浆EL增高,EL在高血压病中有重要意义。

Objective To explore the relation between endothelial lipase （EL） and hypertension, Methods Seventy - seven patients （pts） with hypertension were in hypertension group and 34 healthy volunteers were recruited as control group. The data of history, body height, weight and blood pressure were collected and BMI was calculated. The plasma EL concentration was measured by enzyme- linked immunosorbent assay. Results EL concentration was significant difference between the hypertension group （395.0 ± 65.2） ng/mL and control group （338.7 ± 51.0） ng/mL （P 〈 0.05）. Conclusion EL expression was increased in pts with hypertension. EL might have role on the development of hypertension.