具有生物活性的哌嗪乙酰腙化合物的微波合成及表征

Synthesis and characterization of biological active piperazine acteyl hydrazones derivatives under microwave irradiation

微波辐射条件下,以丙酮作用溶剂,1-[二-(4-氟苯)甲基]哌嗪与氯乙酸乙酯反应得到2-[二-(4-氟苯)甲基]哌嗪乙酸乙酯(1),(1)与水合肼在微波辐射条件下反应得到2-[二-(4-氟苯)甲基]哌嗪乙酰肼(2),进一步在微波辐射条件下由2-[二-(4-氟苯)甲基]哌嗪乙酰肼(2)与取代芳香醛和酮反应制得目标化合物3(a^d).合成的4个目标化合物通过熔点测定和质谱、红外光谱、核磁共振氢谱分析、元素分析对其结构进行确证.

Four hydrazones 3（a-d） are synthesized from following three steps： firstly ethyl 2-[4-bi- （4- fluorophenyl）-methyl- piperazin - 1 - yl]acetate （1） is synthesized by the reaction of I-[bi-（4-fluorophenyl）methyl]-piperazine with ethyl chloroacetate in acetone under microwave irradiation. Then treatment of the compoun （1） with hydrazine to give 2-[4 - bi - （4 - fluorophenyl） -methylpiperazin-l-yl] Acteyl Hydrazine（2）. Finally compound （2） reacted with aromatic aldehydes and ketones under microwave irradiation yielded the corresponding compounds 2-[4-bi-（4-fluorophenyl）-methylpiperazin-l-yl] Acteyl Hydrazones 3（a-d） in good yields. The structures of four new compounds are confirmed by IR, ^1H NMR, MS spectra and elemental analysis.