曲美他嗪治疗不稳定性心绞痛合并糖尿病老年患者的临床研究

Effects of trimetadizine in the elderly patients with unstable angina pectoris and diabetes mellitus

目的探讨曲美他嗪治疗不稳定性心绞痛合并糖尿病老年患者的疗效。方法70例老年不稳定性心绞痛合并糖尿病患者随机分为曲美他嗪治疗组(35例)和常规治疗组(35例),曲美他嗪治疗组在常规口服药物基础上加用曲美他嗪20 mg口服,每日3次,治疗8周后观察每周心绞痛发作次数及硝酸酯类制剂用量、左心室舒张末径(LVEDd)、左心室射血分数(LVEF)、ST段下降导联数(NST)、ST段压低总和(ΣST)变化。结果经8周治疗后两组均可显著改善心肌缺血程度及心功能,降低心绞痛发作频率和硝酸甘油日耗量,且曲美他嗪治疗效果优于常规治疗组。结论在常规治疗基础上加用曲美他嗪能更有效改善老年不稳定性心绞痛合并糖尿病患者心肌缺血及心功能。

Objective To evaluate the therapeutic effect of trimetadizine in the elderly patients with unstable angina pectoris and diabetes mellitus. Methods 70 old patients with unstable angina pectoris and diabetes mellitus were divided into trimetadizine group （ n = 35 ） and traditional medicine therapy group （ n = 35 ）. All patients were treated with routine medicine therapy, patients in trimetadizine group were given trimetadizine 20mg three times daily for 8 weeks. The occurrence of angina and nitrates consumption per week, LVEDd, LVEF ,NST,EST were evaluated before and after the trial. Results After 8 weeks treatment, the frequency of angina pectoris, the weekly consumption of nitroglycerin decreased significantly both in trimetadizine group and the control group with improved heart function and the degree of myocardial ischemia, the efficacy was better in trimetadizine group. Conclusion Combined therapy of trimetadizine and conventional drugs could improve the heart function and myocardial ischemia of the elderly patients with unstable angina pectoris and diabetes mellitus more effectively.