血清6-keto-PGE_1α水平对监测盘源性腰痛的临床价值

Clinical significance of the level of serum 6-keto-PGE_1α between discogenic low lack pain

目的对血清前列腺素E(2PGE2)代谢产物6-keto-PGE1α与退变椎间盘渗透性改变的相关性进行研究,探讨PGE2作为反映盘源性腰痛的特异性炎症指标的可能性。方法①收集20例盘源性腰痛分为治疗前和治疗后两组,分别测定两组血清标本前列腺素E2水平。②采用同期健康献血者10名,作为健康对照组。结果A组(盘源性腰痛患者治疗前)53.8470±13.763pg/ml,B组(盘源性腰痛患者治疗后)46.1025±5.516pg/ml,A组明显高于B组及C组,差异具有显著性(P<0.05)。对A、B两组资料进行配对t检验发现t=2.875,经双尾检验P<0.05,盘源性腰痛患者治疗前后差异具有显著性意义。结论①前列腺素E2与盘源性腰痛炎症机制密切相关。②监测血清6-keto-PGE1α能很好的反映出椎间盘内的渗透性变化和盘内炎症水平。

Objective To study the dependability between Serum 6-keto-PGE1α Level and sig- nificance of discogentic low back pain＇s permeability change,discuss the reliability of serum 6-keto-PGE1α as a inflammation marker in discogentic low back pain. Methods ①20 patients were randomly selected and divided into 2 groups：pre-treatment and post-treament. Serum 6-keto-PGElet concentration were measured before therapy and after therapy. ②10 volunteer peoples who were health blood donor,as the control group B. and measured serum 6-keto-PGE1α. Results The serum 6-keto-PGElet level in group A,B were 53.8470±13.763pg/ml,46.1025±5.516pg/ml. Through analysis by SPSS,we found the concentration of serum 6-keto-PGE1α in Group A is much higher than in group B and C,The difference is significant（P〈0.05）. By paired T analysis,group A and B result T=2.875. The difference between group A,B （before therapy and after therapy）was significant （2-tail,P〈0.05）. Conclusion ①6-keto-PGE1α has been proved high compact with discogentic low back pain. ②Monitoring Serum 6-keto-PGE1α level can well reflect the discogentic low back pain＇s permeability changes and inflammation level in intercalated disc.