昆虫类免疫球蛋白结构和功能研究进展

Advances in insect hemolin structure and function

类免疫球蛋白是在无脊椎动物体内发现的唯一的免疫球蛋白家族成员,它对鳞翅目昆虫自身的免疫起着重要的作用。已有研究表明:类免疫球蛋白只存在于鳞翅目昆虫体内,有可溶性和不溶性两种存在方式,在昆虫体内分别具有不同的功能。可溶性类免疫球蛋白通过一些酶和蛋白的作用对入侵昆虫的细菌和病毒进行免疫防御,而不溶性类免疫球蛋白(即以膜结合蛋白的形式出现)对细胞和细胞黏着以及病毒和细菌入侵细胞有着延缓作用。

Hemolin is the only member of the immunoglobulin superfamily in invertebrates so far. It plays an important role in Lepidoptera immunity. Based on more than 40 literatures on hemolin, we found that hemolin appears only in Lepidoptera, and exists in the two modes, dissoluble and infusible, which show different biological functions. Dissoluble hemolin could resist invading pathogens, such as bacterium and virus by some enzymes and proteins, while the infusible hemolin may have catabatic effect on cell-cell adhesion and virus or bacterium invading cell.