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rBCG-HPV16 E6-E7疫苗和rBCG-HPV16 L1-E7疫苗对人子宫颈癌小鼠的治疗作用和免疫机制研究 被引量：2

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摘要 目的研究rBCG-HPV16 E6-E7疫苗和rBCG-HPV16 L1-E7疫苗对子宫颈癌的治疗作用及免疫机制。方法BALB/C鼠皮下接种人子宫颈癌细胞系CaSki细胞构建子宫颈癌模型,用本研究组制备的rBCG-HPV16 E6-E7疫苗和rBCG-HPV16 L1-E7疫苗皮下分别注射进行治疗,观察肿瘤的生长情况。结果皮下注射rBCG-HPV16 E6-E7疫苗和rBCG-HPV16 L1-E7疫苗后,肿瘤体积显著缩小,小鼠存活期明显长于对照组,肿瘤瘤体内CD8+细胞浸润增加;肿瘤细胞表达H-2Db和B7-1分子明显增加。rBCG-HPV16 E6-E7疫苗效果强于rBCG-HPV16 L1-E7疫苗。结论rBCG-HPV16 E6-E7疫苗和rBCG-HPV16 L1-E7疫苗对子宫颈癌有治疗作用。
作者 李翎 罗红敏 赛林霖 赵立民 刘晖
机构地区 山东省职业卫生与职业病研究院 山东省肿瘤防治研究院
出处 《实用肿瘤杂志》 CAS 2008年第3期236-239,共4页 Journal of Practical Oncology
基金 山东省科技攻关计划项目资助(No022100119)
关键词 宫颈肿瘤 癌症疫苗 乳头状瘤病毒 人 基因
分类号 R737.33 [医药卫生—肿瘤] R730.54 [医药卫生—肿瘤]
  • 相关文献

参考文献10

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共引文献9

同被引文献24

  • 1孙建衡.子宫颈癌治疗的回顾与展望[J].中华肿瘤杂志,2006,28(2):159-160. 被引量：21
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引证文献2

二级引证文献5

实用肿瘤杂志
2008年 第3期

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