慢性乙型肝炎患者血清铁、铁蛋白水平与脂质过氧化损伤的关系

Relationship between serum Iron、Ferritin and lipid peroxidation injury in patients with chronic hepatitis B.

目的探讨慢性乙型肝炎（CHB）患者血清铁（SI）、铁蛋白（SF）水平与脂质过氧化损伤的关系。方法选择79例CHB患者，用比色法测SI、放射免疫法测SF、硫代巴比妥酸法测丙二醛（MDA）、黄嘌呤氧化酶法测超氧化物歧化酶（SOD）。结果各组CHB患者SI、SF和MDA水平均高于对照组（P〈0．05～0．01），SOD水平均低于对照组（P〈0．01）。79例CHB患者SI、FE水平与MDA水平均正相关（r=0．493，P〈0．01；r=0．745。P〈0．01）；SI水平与SOD水平负相关（r=-0．27，P〈0．05）。结论CHB患者SI、SF水平与脂质过氧化损伤有相关性，过重的铁负荷协同乙肝病毒加重肝损伤。

Objective To investigate the relationship between serum iron（SI）, serum ferritin （SF） and lipid pemxidation injury in patients with chronic hepatitis B. Methods 79 patients with chronic hepatitis B were enrolled in this study. SI was detected by chromatometry, SF by Radio -immunity, MDA by thiobarbituric acid method, and SOD by xanthineoxidase method. Results Compared to control group, the level of SI, FE and MDA in patients with chronic hepatitis B were higher significantly （ P 〈 0. 05 - 0. 01 ）. On the contrary, the level of SOD in patients with chronic hepatitis B was lower significantly （ P 〈 0. 01 ）. In 79 patients with chronic hepatitis B, correlation analyses found that SI and FE were in positive correlation with MDA（ r = 0. 493, P 〈 0. 01, r = 0. 745, P 〈 0. 01 ）, and SI was in negative correlation with SOD （ r = - 0. 27, P 〈 0. 05）. Conclusion The levels of SI and SF in patients with chronic hepatitis B are closely related to lipid peroxidation injury, and the overload of iron may enhance the hepatocytes damage induced by HBV.