ALT小于2×ULN慢性乙型肝炎患者的肝组织病理学分析

Pathological characterization of the chronic hepatitis B with ALT less than 2×ULN/L

目的观察ALT小于2×ULN慢性乙型肝炎患者的肝组织病理学与ALT的相关性。方法选择符合诊断标准的303例慢性乙型肝炎患者,检测血清肝功能、进行肝脏活检,肝脏组织标本进行常规病理检测。结果ALT小于2×ULN慢性乙型肝炎患者肝组织64.68%有2级以上的炎症改变,56.44%有2期以上的纤维化。本组中ALT男性均值为(39.73±19.14)U/L,女性为(29.21±13.90)U/L。结论ALT与炎性分级、纤维化分期均有相关性。ALT正常与不正常的慢性乙型肝炎患者肝脏组织炎性分级、纤维化分期不同,随着ALT数值的升高肝组织炎症及纤维化改变越明显。

Objective To analyze the relationships between alanine aminotransferase （ALT） and hepatic histopathology in chronic hepatitis B（CHB） patients with ALT2 × ULN/L. Methods 303 patients with the diagnosis of CHB, the liver functions were tested and the pathological changes were shown by liver biopsy. Results The inflammatory grade was at 2 stage or higher in 64. 68% of patients and the hepatic fibrosis degree were at 2 stage and higher in 56. 44% of patients. The relationship between ALT and inflammatory grade/fibrotic stage was positive correlation. Conclusion There were differences of inflammatory grade/fibrotic stage between patients with normal ALT and patients with abnormal ALT. The inflammatory and fibrosis in liver progressed along with the increasing of ALT.