磷酸化蛋白50(EBP50)——一种新的抑癌蛋白

EBP50:a Novel Cancer Suppressor Protein

磷酸化蛋白50(ERM-binding phosphoprotein-50,EBP50)是由358个氨基酸组成的多功能连接蛋白.EBP50通过其PDZ-Ⅰ、PDZ-Ⅱ和ERM结合结构域与多种蛋白质结合,对PI3K/Akt、PLCβ等生长信号途径及对细胞迁移进行调控.目前有很多证据提示,ebp50是一种新的抑癌基因.在乳腺癌病人临床标本和细胞系中可检测到ebp50基因的杂合性丢失(LOH)和突变,其抑癌作用可能是通过它与多种抑癌蛋白(如抑癌蛋白PTEN、MERLIN和SYK)的相互作用并增强它们的稳定性,并与致癌蛋白结合从而抑制其致癌功能来达到的.通过对其分子结构、调控的信号途径及其与乳腺癌发生、发展的关系进行综述,为乳腺癌的防治提供新线索.

EBP50 （ERM-binding phosphoprotein-50）, a multifunctional adapter protein with 358 amino acids and two PDZ domains, regulates cell growth and migration. Lines of evidences indicate that it is a potential cancer suppressor protein. Loss of heterozygosity （LOH） and intragenic mutation of the ebp50 gene have been found in both primary breast tumors and breast cancer cell lines. EBP50 suppresses the breast cancer cell proliferation via its interaction with many tumor suppressor Protein including PTEN, SYK, MERLIN, etc. Here the molecular structure of EBPS0, signal pathway regulated by EBP50, and the relationship between breast cancer development and EBP50 are discussed.