以HBeAg为指标的手术中传染源监控方法的分析

An analysis of HBeAg-indicated measure for controlling HBV infective source during operition

目的分析以HBeAg为指标的手术中HBV传染源监控方法的特点。方法在确定HBV经手术感染的阈值和HBV传染性定量检测基础上,分析以HBeAg为指标的手术中HBV传染源监控方法的特点。结果HBV经单层手套传播的感染阈值为105ID/ml。HBsAg阴性手术患者9.0%HBVDNA阳性,传染性0～104ID/ml。HBeAg阴性、HBeAg阳性、HBsAg阳性者的传染性达感染阈值的比率分别为3.2%、83.9%和19.2%。18.6%HBsAg阳性者的传染性在乙肝疫苗低度反应者的防护范围之内,0.6%患者超过这一防护范围,且超过者均为HBeAg阳性。结论HBeAg为指标的手术中HBV传染源监控方法属零危险性的防护标准。

Objective To analyze characteristics of HBeAg-indicated measure for controlling HBV infective source during operition. Methods On the basis of the determination of HBV infective threshold value during operation and the HBV infective quantitative test, the characteristics of HBeAg-indicated measure for controlling HBV infective source during operition were analyzed. Results HBV infective threshold value of single layer gloves was 10^5 ID/ml. 9.0% HBsAg negative patients was HBV DNA positive,with the infectivity of 0~104 ID/ml. The ratios of HBeAg negative, HBeAg positive and HBsAg positive patients, whose infectivities reached HBV infective threshold value, were 3. 2%, 83. 9% and 19.2%, respectively. The infectivity of 18.6% HBsAg positive patients was under the protection margin of HBV vaccine responder, which of 0.64 % HBeAg positive patients was over that. Conclusion The measure of HBeAg served as a supervising and controlling index of HBV infective source during operation is a zero risk precautionary standard.