喉源性咳嗽患者的吸入性变应原及血清特异性IgE检测

Inhalant allergen and serum specific IgE detection of laryngeal cough

目的探讨喉源性咳嗽与变态反应性炎症的相关性。方法66例喉源性咳嗽患者分为不伴有(A)和伴有(B)变应性鼻炎两组。应用吸入性变应原皮肤试验并检测外周血嗜酸性粒细胞(EOS)计数,采用瑞典法玛西亚CAP系统进行吸入性过敏原过筛定量(血清特异性IgE)测定。其结果与27例正常人(C组)对照。结果A组吸入性变应原皮试、EOS计数及血清特异性IgE检测结果与C组相仿(P>0.05)。而B组各项检查结果均明显高于A、C两组(P<0.05)。结论伴变应性鼻炎的喉源性咳嗽可能与变态反应性炎症有关,而不伴变应性鼻炎的喉源性咳嗽患者中多数患者与变态反应性炎症关系不大。

Objective To determine if significant relation exists between laryngeal cough and allergic inflammation. Methods Twenty-seven healthy volunteers and sixty-six patients clinically diagnosed as laryngeal cough entered the study. The patients were divided into the cases with allergic rhinitis （group B） and those without allergic rhinitis（ group A）. The serum eosinophilic granulocyte and inhalant allergen skin test were performed and specific IgE was measured by Sweden Pharmacia CAP system. Results There was no statistical difference in inhalant allergen, eosinophilic granulocyte and specific IgE between group A and the healthy volunteers （group C）, which were significantly higher in group B than those in group A and C （P〈0.05）. Conclusion The laryngeal cough with allergic rhinitis may be related with allergic inflammation.